To enhance biocompatibility of neural electrode, residual solvent in the neural electrode was reduced by solvent extraction and ultra-sonication processes. The solvent-extracted polyimide (PI) films are subcutaneously implanted in the mouse. The biocompatibility of the PI film was analyzed using the cytotoxicity, RT-PCR, and H & E staining. The solvent-extracted PI film shows better short term biocompatible characteristics over control and non-treated PI film. This solvent reduction method can be used to increase the biocompatibility of neural electrode.
Key words : neural electrode, polyimide, biocompatibility, nerve regeneration
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