This study was aimed at confirming the recovery of damaged bone tissue by using SB-1TM as a synthetic bone in
clinical and in vivo studies. SB-1TM consists of 500~1400 μm synthetic hydroxyapatite (HAp) particles and has the
same chemical composition as that of the inorganic part of human bones. Since SB-1TM is mainly composed of
HAp and has excellent bioactivity, the graft integrated well with the surrounding host bone and promoted the
induction of the new bone, thereby leading to bonding with the newly formed bone and recovery of the damaged
bone tissue. Patients with damaged bones were surgically treated with SB-1TM, and bone recovery was monitored
radiographically. In an in vivo study employing rabbits with tibial defects, SB-1TM showed superior bonding with the
host bones and superior integration with the new bone as compared to those shown by allografts and bone grafts
with low HAp content.
Key words: hydroxyapatite, bone regeneration, synthetic bone, SB-1TM
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